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lumacaftor/ivacaftor will lower the level or result of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers cuts down plasma focus of abemaciclib and its metabolites.duvelisib will raise the degree or impact of abemaciclib by impacting hepati